| Zeitraum | 1. Vorsitzender des TZB |
| seit 2024 | Prof. Dr. med. Maike de Wit |
| 2020–2023 | Prof. Dr. med. Ulrich Keilholz (Charité Comprehensive Cancer Center) |
| 2018–2020 | Prof. Dr. med. Martin Strik (Tumorzentrum Berlin-Buch) |
| 2014–2016 | Prof. Dr. med. Ulrich Keilholz (Charité Comprehensive Cancer Center) |
| 2012–2014 | PD Dr. med. Harald Matthes (Tumorzentrum gemeinnütziger & konfessioneller Krankenhäuser in Berlin e.V. (TZGKB) |
| 2010–2012 | Prof. Dr. med. Dr. phil. Alfred Holzgreve (Vivantes Tumorzentrum) |
| 2008–2010 | Prof. Dr. med. Volker Budach (TZ Berlin-Charité) |
| 2006–2008 | Prof. Dr. med. Ernst Späth-Schwalbe (TZ Spandau) |
| 2004–2006 | PD Dr. med. Günter Morack (TZ Berlin-Buch) |
| 2002–2004 | Prof. Dr. med. Wolfgang Hinkelbein (TZ Benjamin Franklin) |
| 2000–2002 | Prof. Dr. med. Dr. phil. Alfred Holzgreve (TZ Neukölln) |
| 1998–2000 | Prof. Dr. med. Volker Budach (TZ Berlin-Charité) |
| 1996–1998 | Prof. Dr. med. Klaus-Peter Hellriegel (TZ Berlin-Moabit) |